Using computation for neuroactive small molecule synthesis
The Newhouse Group's research centers on technology development for the synthesis of small-molecule natural products and analogs thereof that perturb neuronal function. Many molecules are known to exhibit exciting properties, but are only available in trace quantities either from natural sources or via conventional synthetic organic methodology. Instead, detailed physical organic studies using computational approaches facilitate the development of construction reactions, used to simplify access to neurologically active probe compounds for receptor imaging, cellular and molecular mechanism of action studies, and the development of novel pharmaceuticals.
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Biography
Tim Newhouse received his B.A. in Chemistry from Colby College (2005) in Waterville, ME, where he was mentored by Prof. Dasan M. Thamattoor. He completed his Ph.D. studies in 2010 at The Scripps Research Institute in La Jolla, CA, with Prof. Phil S. Baran. During his time at Scripps, he also worked in the laboratories of Prof. Donna G. Blackmond. He then returned to the east coast for postdoctoral studies with Prof. E.J. Corey at Harvard University. He joined the faculty at Yale in 2013, and as of 2018 he is an Associate Professor at Yale University in the Department of Chemistry. Tim?s research focuses on chemical technologies and computational approaches to enable step-efficient synthesis of neuroactive small molecules.